Title : NF-kappaB transcription factor induces drug resistance through MDR1 expression in cancer cells.

Pub. Date : 2003 Jan 9

PMID : 12527911






2 Functional Relationships(s)
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1 We observed that NF-kappaB or P-glycoprotein inhibition in the HCT15 colon cancer cells led to increased apoptotic cell death in response to daunomycin treatment. Daunorubicin nuclear factor kappa B subunit 1 Homo sapiens
2 Interestingly, NF-kappaB inhibition through transfection of a plasmid coding for a mutated IkappaB-alpha inhibitor increased daunomycin cell uptake. Daunorubicin nuclear factor kappa B subunit 1 Homo sapiens