Title : Improved biological activity of Gly2- and Ser2-substituted analogues of glucose-dependent insulinotrophic polypeptide.

Pub. Date : 2003 Jan

PMID : 12525257






2 Functional Relationships(s)
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1 Therefore, this study examined the plasma stability, biological activity and antidiabetic potential of two novel NH2-terminal Ala2-substituted analogues of GIP, containing glycine (Gly) or serine (Ser). Glycine gastric inhibitory polypeptide Homo sapiens
2 These data indicate that substitution of the penultimate Ala2 in GIP by Gly or Ser confers resistance to plasma DPP IV degradation, resulting in enhanced biological activity, therefore raising the possibility of their use in the treatment of type 2 diabetes. Glycine gastric inhibitory polypeptide Homo sapiens