Title : Microglial function in human APOE3 and APOE4 transgenic mice: altered arginine transport.

Pub. Date : 2003 Jan

PMID : 12507771






5 Functional Relationships(s)
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Protein Name
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1 Our data demonstrate that arginine uptake is enhanced in APOE4 microglia compared to APOE3 microglia. Arginine apolipoprotein E Homo sapiens
2 The increased arginine uptake in APOE4 Tg microglia is associated with an increased expression of mRNA for cationic amino acid transporter-1 (Cat1), a constuitively expressed member of the arginine selective transport system (the y+ transport system) found in most cells. Arginine apolipoprotein E Homo sapiens
3 The increased arginine uptake in APOE4 Tg microglia is associated with an increased expression of mRNA for cationic amino acid transporter-1 (Cat1), a constuitively expressed member of the arginine selective transport system (the y+ transport system) found in most cells. Arginine apolipoprotein E Homo sapiens
4 This change in microglial arginine transport suggests a potential impact of the APOE4 gene allele on those biochemical pathways such as NO production or cell proliferation to which arginine contributes. Arginine apolipoprotein E Homo sapiens
5 This change in microglial arginine transport suggests a potential impact of the APOE4 gene allele on those biochemical pathways such as NO production or cell proliferation to which arginine contributes. Arginine apolipoprotein E Homo sapiens