Title : Down-regulation of deoxycytidine kinase in human leukemic cell lines resistant to cladribine and clofarabine and increased ribonucleotide reductase activity contributes to fludarabine resistance.

Pub. Date : 2003 Jan 15

PMID : 12504799






1 Functional Relationships(s)
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1 The CdA and CAFdA resistant cells displayed a deficiency in dCK activity (to <5%) while the Fara-A resistant cells showed only a minor reduction of dCK activity (20% reduction). fludarabine Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster