Title : Understanding the catalytic mechanism of GTPase-activating proteins: demonstration of the importance of switch domain stabilization in the stimulation of GTP hydrolysis.

Pub. Date : 2002 Dec 31

PMID : 12501193






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The cycling of Cdc42 between its on (GTP-bound) and off (GDP-bound) states is essential for its stimulation of cell growth and transformation, with an important aspect of this cycle being the regulation of the GTP hydrolytic activity of Cdc42 by its GTPase-activating protein (Cdc42GAP). Guanosine Diphosphate cell division cycle 42 Homo sapiens
2 The cycling of Cdc42 between its on (GTP-bound) and off (GDP-bound) states is essential for its stimulation of cell growth and transformation, with an important aspect of this cycle being the regulation of the GTP hydrolytic activity of Cdc42 by its GTPase-activating protein (Cdc42GAP). Guanosine Diphosphate cell division cycle 42 Homo sapiens