Title : CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling.

Pub. Date : 2003 Feb

PMID : 12496963






1 Functional Relationships(s)
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1 Both basal Lck activity in unstimulated cells and the TCR-induced increase in tyrosine phosphorylation of the TCR zeta-chain and in Lck activity depend on the expression of CD45 with a large ectodomain. Tyrosine LCK proto-oncogene, Src family tyrosine kinase Homo sapiens