Title : Cisplatin-induced activation of the EGF receptor.

Pub. Date : 2002 Dec 12

PMID : 12483525






15 Functional Relationships(s)
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1 Cisplatin-induced activation of the EGF receptor. Cisplatin epidermal growth factor receptor Homo sapiens
2 Here we report that CDDP also activates a membrane-integrated protein, the epidermal growth factor receptor (EGFR). Cisplatin epidermal growth factor receptor Homo sapiens
3 Here we report that CDDP also activates a membrane-integrated protein, the epidermal growth factor receptor (EGFR). Cisplatin epidermal growth factor receptor Homo sapiens
4 We show that EGFR is activated in response to CDDP in various types of cells that overexpress the receptor, including transformed human glioma cells and human breast tumor cells. Cisplatin epidermal growth factor receptor Homo sapiens
5 CDDP-induced EGFR activation requires its kinase activity, as it can be blocked by an EGFR kinase inhibitor or by expression of a kinase dead receptor. Cisplatin epidermal growth factor receptor Homo sapiens
6 CDDP-induced EGFR activation requires its kinase activity, as it can be blocked by an EGFR kinase inhibitor or by expression of a kinase dead receptor. Cisplatin epidermal growth factor receptor Homo sapiens
7 We also show that CDDP-induced EGFR activation is independent of receptor ligand. Cisplatin epidermal growth factor receptor Homo sapiens
8 CDDP induces the activation of c-Src, and EGFR activation is blocked by Src-family inhibitor PP1, suggesting that Src kinases mediate CDDP-induced EGFR activation. Cisplatin epidermal growth factor receptor Homo sapiens
9 CDDP induces the activation of c-Src, and EGFR activation is blocked by Src-family inhibitor PP1, suggesting that Src kinases mediate CDDP-induced EGFR activation. Cisplatin epidermal growth factor receptor Homo sapiens
10 CDDP induces the activation of c-Src, and EGFR activation is blocked by Src-family inhibitor PP1, suggesting that Src kinases mediate CDDP-induced EGFR activation. Cisplatin epidermal growth factor receptor Homo sapiens
11 We propose that EGFR activation in response to CDDP is a survival response, since inhibition of EGFR activation enhances CDDP-induced death. Cisplatin epidermal growth factor receptor Homo sapiens
12 We propose that EGFR activation in response to CDDP is a survival response, since inhibition of EGFR activation enhances CDDP-induced death. Cisplatin epidermal growth factor receptor Homo sapiens
13 We propose that EGFR activation in response to CDDP is a survival response, since inhibition of EGFR activation enhances CDDP-induced death. Cisplatin epidermal growth factor receptor Homo sapiens
14 These findings show that signals generated by DNA damage can modulate EGFR activity, and argue that interfering with CDDP-induced EGFR activation in tumor cells might be a useful approach to sensitize these cells to genotoxic agents. Cisplatin epidermal growth factor receptor Homo sapiens
15 These findings show that signals generated by DNA damage can modulate EGFR activity, and argue that interfering with CDDP-induced EGFR activation in tumor cells might be a useful approach to sensitize these cells to genotoxic agents. Cisplatin epidermal growth factor receptor Homo sapiens