Title : Mitogen-activated protein kinases contribute to reactive oxygen species-induced cell death in renal proximal tubule epithelial cells.

Pub. Date : 2002 Dec

PMID : 12482247






3 Functional Relationships(s)
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Protein Name
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1 TGHQ-induced phosphorylation of ERK1/2 and JNK MAPKs required epidermal growth factor receptor (EGFR) activation, whereas p38 MAPK activation was EGFR independent. 2,3,5-(triglutathion-S-yl)hydroquinone mitogen-activated protein kinase 1 Homo sapiens
2 In contrast to their established roles in cell survival, TGHQ-activated ERK1/2 and p38 MAPK (but not JNK) appear to contribute to cell death, since inhibition of ERK1/2 or p38 MAPKs with PD098059 or SB202190 respectively, attenuated TGHQ-mediated cell death. 2,3,5-(triglutathion-S-yl)hydroquinone mitogen-activated protein kinase 1 Homo sapiens
3 In contrast to their established roles in cell survival, TGHQ-activated ERK1/2 and p38 MAPK (but not JNK) appear to contribute to cell death, since inhibition of ERK1/2 or p38 MAPKs with PD098059 or SB202190 respectively, attenuated TGHQ-mediated cell death. 2,3,5-(triglutathion-S-yl)hydroquinone mitogen-activated protein kinase 1 Homo sapiens