Pub. Date : 2002 Dec
PMID : 12482247
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Extracellular signal-regulated kinases (ERK1/2), c-Jun N-terminal kinases (JNK/SAPK), and p38 mitogen-activated protein kinase (MAPK) were all rapidly activated in a ROS-dependent manner during 2,3,5-tris-(glutathion-S-yl)hydroquinone (TGHQ)-mediated oxidative stress and oncotic cell death in renal proximal tubule epithelial cells (LLC-PK1). | 2,3,5-(triglutathion-S-yl)hydroquinone | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | Extracellular signal-regulated kinases (ERK1/2), c-Jun N-terminal kinases (JNK/SAPK), and p38 mitogen-activated protein kinase (MAPK) were all rapidly activated in a ROS-dependent manner during 2,3,5-tris-(glutathion-S-yl)hydroquinone (TGHQ)-mediated oxidative stress and oncotic cell death in renal proximal tubule epithelial cells (LLC-PK1). | 2,3,5-(triglutathion-S-yl)hydroquinone | mitogen-activated protein kinase 3 | Homo sapiens |
| 3 | Extracellular signal-regulated kinases (ERK1/2), c-Jun N-terminal kinases (JNK/SAPK), and p38 mitogen-activated protein kinase (MAPK) were all rapidly activated in a ROS-dependent manner during 2,3,5-tris-(glutathion-S-yl)hydroquinone (TGHQ)-mediated oxidative stress and oncotic cell death in renal proximal tubule epithelial cells (LLC-PK1). | 2,3,5-(triglutathion-S-yl)hydroquinone | mitogen-activated protein kinase 3 | Homo sapiens |
| 4 | TGHQ-induced phosphorylation of ERK1/2 and JNK MAPKs required epidermal growth factor receptor (EGFR) activation, whereas p38 MAPK activation was EGFR independent. | 2,3,5-(triglutathion-S-yl)hydroquinone | mitogen-activated protein kinase 3 | Homo sapiens |
| 5 | In contrast to their established roles in cell survival, TGHQ-activated ERK1/2 and p38 MAPK (but not JNK) appear to contribute to cell death, since inhibition of ERK1/2 or p38 MAPKs with PD098059 or SB202190 respectively, attenuated TGHQ-mediated cell death. | 2,3,5-(triglutathion-S-yl)hydroquinone | mitogen-activated protein kinase 3 | Homo sapiens |
| 6 | In contrast to their established roles in cell survival, TGHQ-activated ERK1/2 and p38 MAPK (but not JNK) appear to contribute to cell death, since inhibition of ERK1/2 or p38 MAPKs with PD098059 or SB202190 respectively, attenuated TGHQ-mediated cell death. | 2,3,5-(triglutathion-S-yl)hydroquinone | mitogen-activated protein kinase 3 | Homo sapiens |