Pub. Date : 2002 Dec
PMID : 12482247
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Extracellular signal-regulated kinases (ERK1/2), c-Jun N-terminal kinases (JNK/SAPK), and p38 mitogen-activated protein kinase (MAPK) were all rapidly activated in a ROS-dependent manner during 2,3,5-tris-(glutathion-S-yl)hydroquinone (TGHQ)-mediated oxidative stress and oncotic cell death in renal proximal tubule epithelial cells (LLC-PK1). | 2,3,5-(triglutathion-S-yl)hydroquinone | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | TGHQ-induced phosphorylation of ERK1/2 and JNK MAPKs required epidermal growth factor receptor (EGFR) activation, whereas p38 MAPK activation was EGFR independent. | 2,3,5-(triglutathion-S-yl)hydroquinone | mitogen-activated protein kinase 8 | Homo sapiens |