Title : Mutation of glutamic acid residue 1046 abolishes Jak2 tyrosine kinase activity.

Pub. Date : 2002 Dec

PMID : 12482029






1 Functional Relationships(s)
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1 The ability of angiotensin II to activate the Jak/STAT signaling pathway in cells expressing the E1046R mutant was severely compromised as measured by reduced (1) Jak2 autophosphorylation (2) Jak2 kinase activity (3) AT1/Jak2 co-association (4) Stat1 tyrosine phosphorylation and (5) angiotensin Il-mediated gene transcription. Tyrosine angiotensinogen Homo sapiens