Pub. Date : 2002 Dec
PMID : 12472573
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Arrest of the cell cycle is mediated by retaining an inactivating state of phosphorylation of cyclin-dependent kinase 1 (Cdk1) on tyrosine 15. | Tyrosine | cyclin dependent kinase 1 | Homo sapiens |
| 2 | Arrest of the cell cycle is mediated by retaining an inactivating state of phosphorylation of cyclin-dependent kinase 1 (Cdk1) on tyrosine 15. | Tyrosine | cyclin dependent kinase 1 | Homo sapiens |
| 3 | There was no predicted cell cycle arrest in Bcr-abl-positive derivative cell lines of K562 that did not survive the same genotoxic insult but, paradoxically, Cdk1 tyrosine phosphorylation was enhanced to a higher extent compared with the parental cell line where arrest of the cell cycle was observed. | Tyrosine | cyclin dependent kinase 1 | Homo sapiens |
| 4 | Only HL60 cells that subsequently underwent apoptosis elicited the same effect of increased Cdk1 tyrosine phosphorylation. | Tyrosine | cyclin dependent kinase 1 | Homo sapiens |
| 5 | It is proposed that the augmented tyrosine phosphorylation status of Cdk1 is associated with the abolition of cell survival, in addition to the previously reported induction of cell cycle arrest in myeloid cell lines. | Tyrosine | cyclin dependent kinase 1 | Homo sapiens |