Pub. Date : 2003 Jan 1
PMID : 12464252
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21. | ent-progesterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 2 | To probe the active site topologies of these related enzymes, we synthesized the enantiomer of progesterone and determined if ent-progesterone is a substrate or inhibitor of CYP17 and CYP21. | ent-progesterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 3 | Neither enzyme metabolizes ent-progesterone; however, ent-progesterone is a potent competitive inhibitor of CYP17 (K(I)=0.2 microM). | ent-progesterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 4 | Neither enzyme metabolizes ent-progesterone; however, ent-progesterone is a potent competitive inhibitor of CYP17 (K(I)=0.2 microM). | ent-progesterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 5 | We conclude that CYP17 accommodates the stereochemically unnatural ent-progesterone better than CYP21. | ent-progesterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |