Title : Inhibition of enzymes of polyamine biosynthesis by substrate-like O-substituted hydroxylamines.

Pub. Date : 2002 Oct

PMID : 12460114






1 Functional Relationships(s)
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1 To inhibit pyridoxal-5"-phosphate dependent ornithine decarboxylase and pyruvate dependent S-adenosylmethionine decarboxylase, key enzymes of polyamine biosynthesis, a system of substrate-like O-substituted hydroxylamines is suggested. Pyridoxal Phosphate ornithine decarboxylase 1 Homo sapiens