Title : Carbamazepine and oxcarbazepine decrease phenytoin metabolism through inhibition of CYP2C19.

Pub. Date : 2002 Dec

PMID : 12458024






2 Functional Relationships(s)
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1 This study evaluated the hypothesis that CBZ and/or its major metabolite (CBZE) inhibit CYP2C19-mediated phenytoin metabolism using human liver microsomes and cDNA-expressed CYP2C19. carbamazepine epoxide cytochrome P450 family 2 subfamily C member 19 Homo sapiens
2 This study evaluated the hypothesis that CBZ and/or its major metabolite (CBZE) inhibit CYP2C19-mediated phenytoin metabolism using human liver microsomes and cDNA-expressed CYP2C19. carbamazepine epoxide cytochrome P450 family 2 subfamily C member 19 Homo sapiens