Title : Polycyclic aromatic hydrocarbon-inducible DNA adducts: evidence by 32P-postlabeling and use of knockout mice for Ah receptor-independent mechanisms of metabolic activation in vivo.

Pub. Date : 2003 Jan 1

PMID : 12455047






6 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 The Ah receptor (AHR) plays a critical role in the induction of CYP1 enzymes (i.e., CYP1A1, 1A2 and 1B1) by PAHs such as benzo[a]pyrene (BP) and 3-methylcholanthrene (MC). Methylcholanthrene aryl-hydrocarbon receptor Mus musculus
2 The Ah receptor (AHR) plays a critical role in the induction of CYP1 enzymes (i.e., CYP1A1, 1A2 and 1B1) by PAHs such as benzo[a]pyrene (BP) and 3-methylcholanthrene (MC). Methylcholanthrene aryl-hydrocarbon receptor Mus musculus
3 The Ah receptor (AHR) plays a critical role in the induction of CYP1 enzymes (i.e., CYP1A1, 1A2 and 1B1) by PAHs such as benzo[a]pyrene (BP) and 3-methylcholanthrene (MC). Methylcholanthrene aryl-hydrocarbon receptor Mus musculus
4 The Ah receptor (AHR) plays a critical role in the induction of CYP1 enzymes (i.e., CYP1A1, 1A2 and 1B1) by PAHs such as benzo[a]pyrene (BP) and 3-methylcholanthrene (MC). Methylcholanthrene aryl-hydrocarbon receptor Mus musculus
5 On the other hand, DNA adduct formation was markedly suppressed in AHR-null animals exposed to MC, although the major MC-DNA adduct was produced in these animals. Methylcholanthrene aryl-hydrocarbon receptor Mus musculus
6 On the other hand, DNA adduct formation was markedly suppressed in AHR-null animals exposed to MC, although the major MC-DNA adduct was produced in these animals. Methylcholanthrene aryl-hydrocarbon receptor Mus musculus