Pub. Date : 2002 Nov 27
PMID : 12451243
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lowered blood concentration of tacrolimus and its recovery with changes in expression of CYP3A and P-glycoprotein after high-dose steroid therapy. | Steroids | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | CONCLUSION: Our results indicate that the decrease in the blood FK506 concentration caused by high-dose steroid therapy is a consequence of the induction of P-glycoprotein and CYP3A in the liver and intestine, and these changes were reversed within 2 weeks after cessation of steroid therapy. | Steroids | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | CONCLUSION: Our results indicate that the decrease in the blood FK506 concentration caused by high-dose steroid therapy is a consequence of the induction of P-glycoprotein and CYP3A in the liver and intestine, and these changes were reversed within 2 weeks after cessation of steroid therapy. | Steroids | ATP binding cassette subfamily B member 1 | Homo sapiens |