Pub. Date : 2003 Apr 15
PMID : 12446442
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cotreatment with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) enhances imatinib-induced apoptosis of Bcr-Abl-positive human acute leukemia cells. | Vorinostat | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 2 | Cotreatment with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) enhances imatinib-induced apoptosis of Bcr-Abl-positive human acute leukemia cells. | Vorinostat | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 3 | Here we demonstrate that treatment with SAHA (suberoylanilide hydroxamic acid), a known inhibitor of histone deacetylases (HDACs), alone induced p21 and/or p27 expressions but decreased the mRNA and protein levels of Bcr-Abl, which was associated with apoptosis of Bcr-Abl-expressing K562 and LAMA-84 cells. | Vorinostat | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 4 | Here we demonstrate that treatment with SAHA (suberoylanilide hydroxamic acid), a known inhibitor of histone deacetylases (HDACs), alone induced p21 and/or p27 expressions but decreased the mRNA and protein levels of Bcr-Abl, which was associated with apoptosis of Bcr-Abl-expressing K562 and LAMA-84 cells. | Vorinostat | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 5 | Here we demonstrate that treatment with SAHA (suberoylanilide hydroxamic acid), a known inhibitor of histone deacetylases (HDACs), alone induced p21 and/or p27 expressions but decreased the mRNA and protein levels of Bcr-Abl, which was associated with apoptosis of Bcr-Abl-expressing K562 and LAMA-84 cells. | Vorinostat | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 6 | Here we demonstrate that treatment with SAHA (suberoylanilide hydroxamic acid), a known inhibitor of histone deacetylases (HDACs), alone induced p21 and/or p27 expressions but decreased the mRNA and protein levels of Bcr-Abl, which was associated with apoptosis of Bcr-Abl-expressing K562 and LAMA-84 cells. | Vorinostat | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 7 | Cotreatment with SAHA and imatinib (Gleevec) caused more down-regulation of the levels and auto-tyrosine phosphorylation of Bcr-Abl and apoptosis of these cell types, as compared with treatment with either agent alone (P <.05). | Vorinostat | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 8 | Significantly, treatment with SAHA also down-regulated Bcr-Abl levels and induced apoptosis of CD34(+) leukemia blast progenitor cells derived from patients who had developed progressive blast crisis (BC) of chronic myelocytic leukemia (CML) while receiving therapy with imatinib. | Vorinostat | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |