Pub. Date : 2002 Dec 1
PMID : 12444159
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation. | 3,3',4,5'-tetrahydroxystilbene | NFKB inhibitor alpha | Homo sapiens |
| 2 | When examined for the mechanism, we found that piceatannol inhibited TNF-induced IkappaBalpha phosphorylation, p65 phosphorylation, p65 nuclear translocation, and IkappaBalpha kinase activation, but had no significant effect on IkappaBalpha degradation. | 3,3',4,5'-tetrahydroxystilbene | NFKB inhibitor alpha | Homo sapiens |
| 3 | When examined for the mechanism, we found that piceatannol inhibited TNF-induced IkappaBalpha phosphorylation, p65 phosphorylation, p65 nuclear translocation, and IkappaBalpha kinase activation, but had no significant effect on IkappaBalpha degradation. | 3,3',4,5'-tetrahydroxystilbene | NFKB inhibitor alpha | Homo sapiens |
| 4 | When examined for the mechanism, we found that piceatannol inhibited TNF-induced IkappaBalpha phosphorylation, p65 phosphorylation, p65 nuclear translocation, and IkappaBalpha kinase activation, but had no significant effect on IkappaBalpha degradation. | 3,3',4,5'-tetrahydroxystilbene | NFKB inhibitor alpha | Homo sapiens |
| 5 | Overall, our results clearly demonstrate that hydroxyl groups of stilbenes are critical and that piceatannol, a tetrahydroxystilbene, suppresses NF-kappaB activation induced by various inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation. | 3,3',4,5'-tetrahydroxystilbene | NFKB inhibitor alpha | Homo sapiens |