Pub. Date : 2002 Dec 1
PMID : 12444151
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We found that, in addition to the MAP/Erk kinase inhibitor PD098059, the PI 3-kinase inhibitors LY294002 and wortmannin both suppressed Erk activation in M-CSF-treated monocytes, suggesting that 3-phosphorylated products of PI 3-kinase played a role in Erk activation. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | colony stimulating factor 1 | Homo sapiens |
2 | Investigating the biochemical pathways regulated by PI 3-kinase to activate Erk, we found that, in response to M-CSF, normal human monocytes induced reactive oxygen species (ROS), which were suppressed by the PI 3-kinase inhibitor wortmannin but not by the solvent control DMSO or the MAP/Erk kinase inhibitor PD098059. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | colony stimulating factor 1 | Homo sapiens |