Title : Macrophage-colony-stimulating factor-induced activation of extracellular-regulated kinase involves phosphatidylinositol 3-kinase and reactive oxygen species in human monocytes.

Pub. Date : 2002 Dec 1

PMID : 12444151






2 Functional Relationships(s)
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1 We found that, in addition to the MAP/Erk kinase inhibitor PD098059, the PI 3-kinase inhibitors LY294002 and wortmannin both suppressed Erk activation in M-CSF-treated monocytes, suggesting that 3-phosphorylated products of PI 3-kinase played a role in Erk activation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one colony stimulating factor 1 Homo sapiens
2 Investigating the biochemical pathways regulated by PI 3-kinase to activate Erk, we found that, in response to M-CSF, normal human monocytes induced reactive oxygen species (ROS), which were suppressed by the PI 3-kinase inhibitor wortmannin but not by the solvent control DMSO or the MAP/Erk kinase inhibitor PD098059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one colony stimulating factor 1 Homo sapiens