Title : Fgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophils.

Pub. Date : 2003 Mar 1

PMID : 12435267






2 Functional Relationships(s)
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1 The following observations imply that Syk is such a kinase: (i) beta(2) integrins activated Syk in a Src-dependent manner, (ii) Syk was associated with Cbl much longer than Fgr was, and (iii) the Syk inhibitor piceatannol (3,4,3",5"-tetrahydroxy- trans -stilbene) abolished the Cbl-associated kinase activity in an in vitro assay. 3,3',4,5'-tetrahydroxystilbene SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens
2 The following observations imply that Syk is such a kinase: (i) beta(2) integrins activated Syk in a Src-dependent manner, (ii) Syk was associated with Cbl much longer than Fgr was, and (iii) the Syk inhibitor piceatannol (3,4,3",5"-tetrahydroxy- trans -stilbene) abolished the Cbl-associated kinase activity in an in vitro assay. 3,3',4,5'-tetrahydroxystilbene SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens