Title : Enzyme kinetics for the formation of 3-hydroxyquinine and three new metabolites of quinine in vitro; 3-hydroxylation by CYP3A4 is indeed the major metabolic pathway.

Pub. Date : 2002 Dec

PMID : 12433805






3 Functional Relationships(s)
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1 Enzyme kinetics for the formation of 3-hydroxyquinine and three new metabolites of quinine in vitro; 3-hydroxylation by CYP3A4 is indeed the major metabolic pathway. Quinine cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 There was a significant correlation between the formation rates of quinine metabolites and activities of the CYP3A4 selected marker probes. Quinine cytochrome P450 family 3 subfamily A member 4 Homo sapiens
3 This in vitro study demonstrates that 3-hydroxyquinine is the principal metabolite of quinine and CYP3A4 is the major enzyme involved in this metabolic pathway. Quinine cytochrome P450 family 3 subfamily A member 4 Homo sapiens