Title : The cancer preventive flavonoid silibinin causes hypophosphorylation of Rb/p107 and Rb2/p130 via modulation of cell cycle regulators in human prostate carcinoma DU145 cells.

Pub. Date : 2002 Mar-Apr

PMID : 12429923






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Silibinin treatment also resulted in 90 and 70% decrease in CDK4 and CDK2 levels, respectively, but did not alter the protein levels of cyclin D1 and cyclin E. Consistent with its effect on G1 cell cycle regulators, silibinin treated cells exhibited a strong G1 arrest, almost complete growth inhibition, and morphological changes suggestive of differentiation. Silybin cyclin dependent kinase 2 Homo sapiens