Pub. Date : 2002 Nov 15
PMID : 12409225
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PACAP-27 tyrosine phosphorylates mitogen activated protein kinase and increases VEGF mRNAs in human lung cancer cells. | Tyrosine | adenylate cyclase activating polypeptide 1 | Homo sapiens |
| 2 | The effects of pituitary adenylate cyclase activating polypeptide (PACAP) on human lung cancer cell line NCI-1299 mitogen activated protein kinase (MAPK) tyrosine phosphorylation and vascular endothelial cell growth factor (VEGF) expression were investigated. | Tyrosine | adenylate cyclase activating polypeptide 1 | Homo sapiens |
| 3 | PACAP-27 (100 nM) increased MAPK tyrosine phosphorylation 3-fold, 5 min after addition to NCI-H1299 cells. | Tyrosine | adenylate cyclase activating polypeptide 1 | Homo sapiens |
| 4 | PACAP caused tyrosine phosphorylation in a concentration-dependent manner being half-maximal at 10 nM PACAP-27. | Tyrosine | adenylate cyclase activating polypeptide 1 | Homo sapiens |
| 5 | PACAP caused tyrosine phosphorylation in a concentration-dependent manner being half-maximal at 10 nM PACAP-27. | Tyrosine | adenylate cyclase activating polypeptide 1 | Homo sapiens |
| 6 | PACAP-27 or PACAP-38 (100 nM) but not PACAP28-38 or VIP caused increased MAPK tyrosine phosphorylation using NCI-H1299 cells. | Tyrosine | adenylate cyclase activating polypeptide 1 | Homo sapiens |
| 7 | Also, the increase in MAPK tyrosine phosphorylation caused by PACAP-27 was totally inhibited by 10 microM PACAP(6-38), a PAC(1) receptor antagonist or 10 microM PD98059, a MAPKK inhibitor. | Tyrosine | adenylate cyclase activating polypeptide 1 | Homo sapiens |
| 8 | Also, the increase in MAPK tyrosine phosphorylation caused by PACAP-27 was totally inhibited by 10 microM PACAP(6-38), a PAC(1) receptor antagonist or 10 microM PD98059, a MAPKK inhibitor. | Tyrosine | adenylate cyclase activating polypeptide 1 | Homo sapiens |