Pub. Date : 2002
PMID : 12403272
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mevastatin, an inhibitor of HMG-CoA reductase, induces apoptosis, differentiation and Rap1 expression in HL-60 cells. | mevastatin | RAP1A, member of RAS oncogene family | Homo sapiens |
| 2 | Furthermore, mevastatin decreased the amount of an isoprenylated membrane bound Rap1 small GTPase concomitant with an increase in cytosolic Rap1 which occurred before apoptosis and differentiation. | mevastatin | RAP1A, member of RAS oncogene family | Homo sapiens |
| 3 | Furthermore, mevastatin decreased the amount of an isoprenylated membrane bound Rap1 small GTPase concomitant with an increase in cytosolic Rap1 which occurred before apoptosis and differentiation. | mevastatin | RAP1A, member of RAS oncogene family | Homo sapiens |
| 4 | These results suggest that mevastatin-induced apoptosis of HL-60 cells might be caused indirectly by activation of the caspase cascade through the modulation of mitochondrial functions and that some relationship between a certain small GTPase molecule, such as Rap1, and mevastatin-induced apoptosis may exist. | mevastatin | RAP1A, member of RAS oncogene family | Homo sapiens |
| 5 | These results suggest that mevastatin-induced apoptosis of HL-60 cells might be caused indirectly by activation of the caspase cascade through the modulation of mitochondrial functions and that some relationship between a certain small GTPase molecule, such as Rap1, and mevastatin-induced apoptosis may exist. | mevastatin | RAP1A, member of RAS oncogene family | Homo sapiens |