Title : TNF-alpha -induced endothelial cell adhesion molecule expression is cytochrome P-450 monooxygenase dependent.

Pub. Date : 2003 Feb

PMID : 12388057






1 Functional Relationships(s)
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1 We found that in high endothelial venular cells (SVEC4-10), multiple inhibitors of CYP450 monooxygenases (SKF-525a, ketoconazole, troleandomycin, itraconazole) attenuated TNF-alpha induction of MAdCAM-1, whereas NADPH oxidase inhibition (PR-39) did not. Ketoconazole cytochrome P450 family 4 subfamily F member 3 Homo sapiens