Title : Effect of CYP1A2 deficiency on heterocyclic amine DNA adduct levels in mice.

Pub. Date : 2002 Oct

PMID : 12387319






2 Functional Relationships(s)
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1 The contribution of CYP1A2 to the formation of DNA adducts of the cooked meat-derived heterocyclic amines (HCAs) 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) was examined in CYP1A2-null (knock-out, KO) and wild-type (WT) mice. hcas cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus
2 The contribution of CYP1A2 to the formation of DNA adducts of the cooked meat-derived heterocyclic amines (HCAs) 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) was examined in CYP1A2-null (knock-out, KO) and wild-type (WT) mice. hcas cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus