Title : Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide.

Pub. Date : 2002 Oct 29

PMID : 12384576






1 Functional Relationships(s)
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Protein Name
Organism
1 Conformational changes induced by phosphotyrosine recognition promote the binding of the Src homology 3 (SH3) domain of the Abl tyrosine kinase to a proline-rich loop located between the betaD and betaE strands of the SH2 domain (DE loop). Proline ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens