Title : Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response.

Pub. Date : 2002 Dec 20

PMID : 12384496






3 Functional Relationships(s)
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1 In liver, lung, pancreas, erythrocytes, and plasma, however, GSH levels in Gclm(-/-) mice were 9-16% of that in Gclm(+/+) littermates. Glutathione glutamate-cysteine ligase, modifier subunit Mus musculus
2 The major decrease in GSH, combined with diminished GCL activity, rendered Gclm(-/-) fetal fibroblasts strikingly more sensitive to chemical oxidants such as H(2)O(2). Glutathione glutamate-cysteine ligase, modifier subunit Mus musculus
3 We conclude that the Gclm(-/-) mouse represents a model of chronic GSH depletion that will be very useful in evaluating the role of the GCLM subunit and GSH in numerous pathophysiological conditions as well as in environmental toxicity associated with oxidant insult. Glutathione glutamate-cysteine ligase, modifier subunit Mus musculus