Pub. Date : 2001 Dec
PMID : 12374095
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Central to the uracil-misincorporation pathway are the enzymes deoxyuridine nucleotidohydrolase (dUTPase) (EC 3.6.1.23) and uracil-DNA glycoslyase (UDG) (EC 3.2.2.3). | Uracil | Deoxyuridine triphosphatase | Drosophila melanogaster |
| 2 | Under normal conditions, uracil is precluded from DNA by the combined actions of dUTPase and UDG. | Uracil | Deoxyuridine triphosphatase | Drosophila melanogaster |
| 3 | However, during TS inhibition, dUTP pools may accumulate and overwhelm dUTPase, resulting in repeated cycles of uracil misincorporation and detrimental repair leading to strand breaks and cell death. | Uracil | Deoxyuridine triphosphatase | Drosophila melanogaster |