PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12374095-9 2001 Central to the uracil-misincorporation pathway are the enzymes deoxyuridine nucleotidohydrolase (dUTPase) (EC 3.6.1.23) and uracil-DNA glycoslyase (UDG) (EC 3.2.2.3). Uracil 15-21 Deoxyuridine triphosphatase Drosophila melanogaster 97-104 12374095-12 2001 Under normal conditions, uracil is precluded from DNA by the combined actions of dUTPase and UDG. Uracil 25-31 Deoxyuridine triphosphatase Drosophila melanogaster 81-88 12374095-13 2001 However, during TS inhibition, dUTP pools may accumulate and overwhelm dUTPase, resulting in repeated cycles of uracil misincorporation and detrimental repair leading to strand breaks and cell death. Uracil 112-118 Deoxyuridine triphosphatase Drosophila melanogaster 71-78