Title : Prostaglandin F(2alpha) stimulates tyrosine phosphorylation of phospholipase C-gamma1.

Pub. Date : 2002 Oct 11

PMID : 12372399






6 Functional Relationships(s)
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1 Prostaglandin F(2alpha) stimulates tyrosine phosphorylation of phospholipase C-gamma1. Tyrosine phospholipase C gamma 1 Homo sapiens
2 In this study, we investigated the ability of prostaglandin F(2alpha) (PGF(2alpha)) to induce tyrosine phosphorylation of phospholipase C-gamma1 (PLC-gamma1) in cat iris sphincter smooth muscle (CISM) cells. Tyrosine phospholipase C gamma 1 Homo sapiens
3 In this study, we investigated the ability of prostaglandin F(2alpha) (PGF(2alpha)) to induce tyrosine phosphorylation of phospholipase C-gamma1 (PLC-gamma1) in cat iris sphincter smooth muscle (CISM) cells. Tyrosine phospholipase C gamma 1 Homo sapiens
4 PGF(2alpha)(1 microM) stimulated PLC-gamma1 tyrosine phosphorylation in a time- and dose-dependent manner with a maximum increase of 3-fold at 0.5min. Tyrosine phospholipase C gamma 1 Homo sapiens
5 In summary, these findings show that PGF(2alpha) stimulates tyrosine phosphorylation of PLC-gamma1 in CISM cells and indicate that PGF(2alpha)-stimulated tyrosine phosphorylation is responsible for an early signal transduction event. Tyrosine phospholipase C gamma 1 Homo sapiens
6 In summary, these findings show that PGF(2alpha) stimulates tyrosine phosphorylation of PLC-gamma1 in CISM cells and indicate that PGF(2alpha)-stimulated tyrosine phosphorylation is responsible for an early signal transduction event. Tyrosine phospholipase C gamma 1 Homo sapiens