Title : Nitric oxide induces degradation of the neutral ceramidase in rat renal mesangial cells and is counterregulated by protein kinase C.

Pub. Date : 2002 Nov 29

PMID : 12359735






1 Functional Relationships(s)
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1 Moreover, the NO-induced degradation is reversed by the protein kinase C (PKC) activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), and also by the physiological PKC activators platelet-derived growth factor-BB (PDGF), angiotensin II and ATP, resulting in a normalization of neutral ceramidase protein as well as activity. Tetradecanoylphorbol Acetate angiotensinogen Rattus norvegicus