Title : A site-specific mutation of tyrosine hydroxylase reduces feedback inhibition by dopamine in genetically modified cells grafted in parkinsonian rats.

Pub. Date : 2002 Oct

PMID : 12358737






2 Functional Relationships(s)
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1 End-product feedback inhibition has been shown to be mediated by the regulatory domain of TH, and site-specific mutation of serine 40 makes TH less susceptible to dopamine inhibition. Serine tyrosine hydroxylase Rattus norvegicus
2 These data support the hypothesis that mutation of serine 40 attenuates TH end-product inhibition in vivo and illustrates the importance of careful consideration of biochemical pathways and interactions between multiple genes in gene therapy. Serine tyrosine hydroxylase Rattus norvegicus