Pub. Date : 2002 Oct 1
PMID : 12356639
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Iron overload augments angiotensin II-induced cardiac fibrosis and promotes neointima formation. | Iron | angiotensinogen | Rattus norvegicus |
| 2 | We have previously reported that continuous administration of angiotensin II to rats results in an overt iron deposition in the renal tubular epithelial cells, which may have a role in angiotensin II-induced renal damage. | Iron | angiotensinogen | Rattus norvegicus |
| 3 | We have previously reported that continuous administration of angiotensin II to rats results in an overt iron deposition in the renal tubular epithelial cells, which may have a role in angiotensin II-induced renal damage. | Iron | angiotensinogen | Rattus norvegicus |
| 4 | In the present study, we investigated the role of iron in the development of cardiac injury induced by angiotensin II. | Iron | angiotensinogen | Rattus norvegicus |
| 5 | No iron deposits were observed in the hearts of untreated rats, whereas iron deposition was seen in the cells in the subepicardial and granulation regions after angiotensin II infusion. | Iron | angiotensinogen | Rattus norvegicus |
| 6 | Concomitant administration of deferoxamine, an iron chelator, significantly reduced the extent of cardiac fibrosis, which suggests that iron deposition aggravates the cardiac fibrosis induced by angiotensin II. | Iron | angiotensinogen | Rattus norvegicus |
| 7 | Concomitant administration of deferoxamine, an iron chelator, significantly reduced the extent of cardiac fibrosis, which suggests that iron deposition aggravates the cardiac fibrosis induced by angiotensin II. | Iron | angiotensinogen | Rattus norvegicus |
| 8 | Iron overload caused by the administration of iron-dextran resulted in an augmentation of cardiac fibrosis and the generation of neointimal cells in the coronary artery in angiotensin II-infused rats. | Iron | angiotensinogen | Rattus norvegicus |
| 9 | CONCLUSIONS: Cardiac iron deposition may be involved in the development of cardiac fibrosis induced by angiotensin II. | Iron | angiotensinogen | Rattus norvegicus |
| 10 | In addition, iron overload may enhance the formation of neointima under conditions of increased circulating angiotensin II but not catecholamines. | Iron | angiotensinogen | Rattus norvegicus |