Title : Increased K-ras protein and activity in mouse and human lung epithelial cells at confluence.

Pub. Date : 2002 Sep

PMID : 12354753






2 Functional Relationships(s)
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1 In all three cell types, total K-ras p21 increased 2- to 4-fold at confluence, and active K-ras p21-GTP increased 10- to 200-fold. Guanosine Triphosphate KRAS proto-oncogene, GTPase Homo sapiens
2 It was estimated that 0.03% of total K-ras p21 was in the active GTP-bound state at 50% confluence, compared with 1.4% at postconfluence. Guanosine Triphosphate KRAS proto-oncogene, GTPase Homo sapiens