Pub. Date : 2002 Sep
PMID : 12353920
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PGE2 is known to suppress T cell proliferation and IL-2 production in many inflammatory conditions. | Dinoprostone | interleukin 2 | Rattus norvegicus |
| 2 | The treatments of burn-injured animals with PGE2 synthesis blocker indomethacin prevented both the decrease in NFAT and AP-1 binding to IL-2 sequences. | Dinoprostone | interleukin 2 | Rattus norvegicus |
| 3 | These results suggested that the suppression of T cell IL-2 production could result from PGE2-mediated alterations in the T cell signaling molecule p59fyn and NFAT/AP-1. | Dinoprostone | interleukin 2 | Rattus norvegicus |