Title : Molecular genetics and function of NAT1 and NAT2: role in aromatic amine metabolism and carcinogenesis.

Pub. Date : 2002 Sep 30

PMID : 12351146






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 For cancers in which N-acetylation is a detoxification step such as aromatic amine-related urinary bladder cancer, NAT2 slow acetylator phenotype is at higher risk. Nitrogen N-acetyltransferase 2 Homo sapiens
2 In contrast, for cancers in which N-acetylation is negligible and O-acetylation is an activation step such as for heterocyclic amine-related colon cancer, NAT2 rapid acetylator phenotype is at higher risk. Nitrogen N-acetyltransferase 2 Homo sapiens