Title : Cloning and functional characterization of the guinea pig vanilloid receptor 1.

Pub. Date : 2002 Sep

PMID : 12243775






1 Functional Relationships(s)
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1 Olvanil and resiniferatoxin were also effective agonists (EC(50) values of 0.0087 +/- 0.0035 micro M and 0.067 +/- 0.014 micro M, respectively), but 12-phenylacetate 13-acetate 20-homovanillate (PPAHV) and anandamide showed little agonist activity up to 10 micro M. As with human and rat VR1, guinea pig VR1 was also activated by pH below 6.0 and by noxious heat (>42 degrees C). resiniferatoxin transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus