Title : Arsenite inhibits interleukin-6 production in human intestinal epithelial cells by down-regulating nuclear factor-kappaB activity.

Pub. Date : 2002 Oct

PMID : 12241537






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 When cells were transfected with a plasmid expressing the p65 subunit of NF-kappaB, the inhibitory effect of sodium arsenite on NF-kappaB activity and IL-6 production was blunted. sodium arsenite nuclear factor kappa B subunit 1 Homo sapiens
2 These results suggest that sodium arsenite inhibits IL-6 production in enterocytes subjected to an inflammatory stimulus, and that this effect, at least in part, reflects down-regulated NF-kappaB activity. sodium arsenite nuclear factor kappa B subunit 1 Homo sapiens