Title : TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity.

Pub. Date : 2002 Sep

PMID : 12235115






1 Functional Relationships(s)
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1 Inhibitors of TNF-alpha production (GM6001, pentoxifylline) and TNF-alpha Ab"s reduced serum and kidney TNF-alpha protein levels and also blunted the cisplatin-induced increases in TNF-alpha, TGF-beta, RANTES, MIP-2, MCP-1, and IL-1beta, but not ICAM-1, mRNA. N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide tumor necrosis factor Mus musculus