Title : GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma.

Pub. Date : 2002 Sep 15

PMID : 12234979






1 Functional Relationships(s)
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1 Although fenretinide is a partial retinoic acid receptor (RAR)-beta/gamma agonist, RARbeta/gamma antagonists did not block the induction of GADD153 by fenretinide; conversely, the induction of GADD153 was blocked by antioxidants. Fenretinide retinoic acid receptor beta Homo sapiens