Pub. Date : 2002 Sep 15
PMID : 12234979
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma. | Fenretinide | DNA damage inducible transcript 3 | Homo sapiens |
| 2 | Expression of the stress-induced transcription factor, GADD153, was up-regulated at both the protein and mRNA levels in response to fenretinide. | Fenretinide | DNA damage inducible transcript 3 | Homo sapiens |
| 3 | Overexpression of GADD153 increased apoptosis in the presence and absence of fenretinide, whereas reduced expression of GADD153 by expression of antisense DNA abrogated the response to fenretinide. | Fenretinide | DNA damage inducible transcript 3 | Homo sapiens |
| 4 | Overexpression of GADD153 increased apoptosis in the presence and absence of fenretinide, whereas reduced expression of GADD153 by expression of antisense DNA abrogated the response to fenretinide. | Fenretinide | DNA damage inducible transcript 3 | Homo sapiens |
| 5 | These results suggest that fenretinide induces apoptosis via RAR-dependent and -independent pathways in which the RAR-independent pathway is characterized by a fenretinide-dependent increase in 12-LOX activity, leading to the induction of GADD153. | Fenretinide | DNA damage inducible transcript 3 | Homo sapiens |
| 6 | These results suggest that fenretinide induces apoptosis via RAR-dependent and -independent pathways in which the RAR-independent pathway is characterized by a fenretinide-dependent increase in 12-LOX activity, leading to the induction of GADD153. | Fenretinide | DNA damage inducible transcript 3 | Homo sapiens |