Pub. Date : 2002 Oct
PMID : 12228192
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Diclofenac-induced inactivation of CYP3A4 and its stimulation by quinidine. | Diclofenac | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | The decrease in the activity followed time- and concentration-dependent kinetics, required oxidative metabolism, and was resistant to reduced glutathione, suggesting that diclofenac causes a mechanism-based inactivation of cytochrome p450 (p450) 3A4 (CYP3A4). | Diclofenac | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Quinidine, a stimulant of CYP3A4-mediated diclofenac 5-hydroxylation, did not affect the inactivation of CYP3A4 assessed by testosterone 6 beta-hydroxylation activity but accelerated the inactivation assessed by diazepam 3-hydroxylation activity. | Diclofenac | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | These results supported the idea that diclofenac 5-hydroxylation is involved in the inactivation of CYP3A4 and described for the first time a stimulation of mechanism-based inactivation attributable to CYP3A4 heterotropic cooperativity. | Diclofenac | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | These results supported the idea that diclofenac 5-hydroxylation is involved in the inactivation of CYP3A4 and described for the first time a stimulation of mechanism-based inactivation attributable to CYP3A4 heterotropic cooperativity. | Diclofenac | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |