Title : Activation of multiple signaling modules is critical in angiotensin IV-induced lung endothelial cell proliferation.

Pub. Date : 2002 Oct

PMID : 12225947






2 Functional Relationships(s)
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1 Pretreatment of cells with wortmannin and LY-294002, inhibitors of PI3K, or rapamycin, an inhibitor of the mammalian target of rapamycin kinase and p70S6K, diminished the ANG IV-mediated activation of PDK-1 and PKB-alpha as well as phosphorylation of p70S6K. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one ribosomal protein S6 kinase B1 Homo sapiens
2 Pretreatment of cells with wortmannin and LY-294002, inhibitors of PI3K, or rapamycin, an inhibitor of the mammalian target of rapamycin kinase and p70S6K, diminished the ANG IV-mediated activation of PDK-1 and PKB-alpha as well as phosphorylation of p70S6K. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one ribosomal protein S6 kinase B1 Homo sapiens