Title : Selection of small-molecule mediators of the RNA regulation of PKR, the RNA-dependent protein kinase.

Pub. Date : 2002 Sep 2

PMID : 12210987






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The selection revealed a PAC (9-anilinoacridine-4-Hyp-Nap-Nap, where Hyp is trans-4-hydroxyproline and Nap is 1-napthylalanine), able to inhibit the binding of the PKR dsRBD to RNA with an IC(50) value of 10 +/- 5 microM. Hydroxyproline eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens