Pub. Date : 2002
PMID : 12210726
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Okadaic acid stimulates osteopontin expression through de novo induction of AP-1. | Okadaic Acid | secreted phosphoprotein 1 | Homo sapiens |
| 2 | Okadaic acid, a strong non-phorbol ester tumor promoter, is known to stimulate the expression of osteopontin. | Okadaic Acid | secreted phosphoprotein 1 | Homo sapiens |
| 3 | The aim of the present study was to understand the mechanism by which okadaic acid regulates osteopontin gene expression. | Okadaic Acid | secreted phosphoprotein 1 | Homo sapiens |
| 4 | Okadaic acid stimulated osteopontin mRNA expression in several cell lines within 3 h, and the increase in osteopontin mRNA was sustained for 24 h. New protein synthesis was required for the okadaic acid-elicited increase in osteopontin mRNA expression. | Okadaic Acid | secreted phosphoprotein 1 | Homo sapiens |
| 5 | Okadaic acid stimulated osteopontin mRNA expression in several cell lines within 3 h, and the increase in osteopontin mRNA was sustained for 24 h. New protein synthesis was required for the okadaic acid-elicited increase in osteopontin mRNA expression. | Okadaic Acid | secreted phosphoprotein 1 | Homo sapiens |
| 6 | Okadaic acid stimulated osteopontin mRNA expression in several cell lines within 3 h, and the increase in osteopontin mRNA was sustained for 24 h. New protein synthesis was required for the okadaic acid-elicited increase in osteopontin mRNA expression. | Okadaic Acid | secreted phosphoprotein 1 | Homo sapiens |
| 7 | Okadaic acid stimulated osteopontin mRNA expression in several cell lines within 3 h, and the increase in osteopontin mRNA was sustained for 24 h. New protein synthesis was required for the okadaic acid-elicited increase in osteopontin mRNA expression. | Okadaic Acid | secreted phosphoprotein 1 | Homo sapiens |
| 8 | Site-directed mutagenesis and electrophoretic mobility shift assays confirmed that protein binding of the AP-1 consensus sequence is necessary for the okadaic acid-mediated osteopontin gene upregulation. | Okadaic Acid | secreted phosphoprotein 1 | Homo sapiens |
| 9 | These results indicate that de novo induction of the oncoprotein AP-1 is required for okadaic acid-stimulated osteopontin gene upregulation. | Okadaic Acid | secreted phosphoprotein 1 | Homo sapiens |