Title : Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol.

Pub. Date : 2002 Sep

PMID : 12208868






1 Functional Relationships(s)
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1 These results demonstrate that increased expression of ABCG5 and ABCG8 selectively drives biliary neutral sterol secretion and reduces intestinal cholesterol absorption, leading to a selective increase in neutral sterol excretion and a compensatory increase in cholesterol synthesis. Sterols ATP binding cassette subfamily G member 8 Mus musculus