Title : Mechanisms of the apoptotic activity of Cl-F-araA in a human T-ALL cell line, CCRF-CEM.

Pub. Date : 2002 Sep

PMID : 12203101






1 Functional Relationships(s)
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1 Western blot analysis revealed that Cl-F-araA induced a dose- and time-dependent downregulation of Bcl-X(L) and Mcl-1 proteins, and a dose- and time-dependent dephosphorylation of Akt and its downstream effectors (Bad, FKHRL1), particularly in vivo. Clofarabine forkhead box O3 Homo sapiens