Title : Relationship between intestinal iron-transporter expression, hepatic hepcidin levels and the control of iron absorption.

Pub. Date : 2002 Aug

PMID : 12196177






8 Functional Relationships(s)
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1 Relationship between intestinal iron-transporter expression, hepatic hepcidin levels and the control of iron absorption. Iron hepcidin antimicrobial peptide Rattus norvegicus
2 Hepcidin is an anti-microbial peptide predicted to be involved in the regulation of intestinal iron absorption. Iron hepcidin antimicrobial peptide Rattus norvegicus
3 We have examined the relationship between the expression of hepcidin in the liver and the expression of the iron-transport molecules divalent-metal transporter 1, duodenal cytochrome b, hephaestin and Ireg1 in the duodenum of rats switched from an iron-replete to an iron-deficient diet or treated to induce an acute phase response. Iron hepcidin antimicrobial peptide Rattus norvegicus
4 We have examined the relationship between the expression of hepcidin in the liver and the expression of the iron-transport molecules divalent-metal transporter 1, duodenal cytochrome b, hephaestin and Ireg1 in the duodenum of rats switched from an iron-replete to an iron-deficient diet or treated to induce an acute phase response. Iron hepcidin antimicrobial peptide Rattus norvegicus
5 We have examined the relationship between the expression of hepcidin in the liver and the expression of the iron-transport molecules divalent-metal transporter 1, duodenal cytochrome b, hephaestin and Ireg1 in the duodenum of rats switched from an iron-replete to an iron-deficient diet or treated to induce an acute phase response. Iron hepcidin antimicrobial peptide Rattus norvegicus
6 In each case, elevated hepcidin expression correlated with reduced iron absorption and depressed levels of iron-transport molecules. Iron hepcidin antimicrobial peptide Rattus norvegicus
7 In each case, elevated hepcidin expression correlated with reduced iron absorption and depressed levels of iron-transport molecules. Iron hepcidin antimicrobial peptide Rattus norvegicus
8 These data are consistent with hepcidin playing a role as a negative regulator of intestinal iron absorption. Iron hepcidin antimicrobial peptide Rattus norvegicus